Cutting down on fried food could lower prostate cancer risk
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Men who eat deep-fried food at least once a week may be increasing their risk for developing prostate cancer, show findings from a US study. (Source: MedWire News - Oncology)
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Risk of Suicide in Men With Low-Risk Prostate Cancer
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Swedish study reports increased risk of suicide in men diagnosed with prostate cancer. Even patients diagnosed with low-risk, early-stage disease had increased risk within the first 6 months following... (Source: OncologySTAT Journal Scans)
Evolving Concepts in the Management of Drug Resistant Ovarian Cancer: Dose Dense Chemotherapy and the Reversal of Clinical Platinum Resistance
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Ovarian cancer, drug-resistant ovarian cancer, platinum resistance, platinum-based chemotherapy, Cancer Treat Rev, journal, oncology, OncologySTAT, Elsevier, DJ Pinato, J Graham, H Gabra Abstract Despite... (Source: OncologySTAT Journal Scans)
[Cancer and Society] Ginseng: panacea among herbal remedies?
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The briefest of internet searches for ginseng yields instant results about its many properties, including curing erectile dysfunction, depression, and menopausal symptoms. The same search also generates pages showing ways in which ginseng can treat cancer, revitalise patients, and, in particular, tame cancer-related fatigue. (Source: The Lancet Oncology)
The Significance of the HER-2 Status in Esophageal Adenocarcinoma for Survival: An Immunohistochemical and an In Situ Hybridization Study
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Amplification and expression of HER-2 as assessed by silver-enhanced in situ hybridization (SISH) were independently associated with poor cause-specific survival in patients with esophageal adenocarcinoma. Abstract Background:... (Source: OncologySTAT Journal Scans)
Advanced Melanoma: MEK Inhibitor Trametinib Tops Chemotherapy
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The oral selective MEK inhibitor trametinib improved progression-free and overall survival over chemotherapy in patients with metastatic melanoma with a BRAF mutation, according to a new phase III trial. (Source: Cancer Network)
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KIT Inhibition Promising for Select Few
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ORLANDO (IMNG) – Patients who express a KIT genetic abnormality represent a small minority of those with melanoma, but there is a lot of interest in the development of specific inhibitors, said Dr. Richard... (Source: OncologySTAT Latest News)
Smartphone melanoma apps cause for concern
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Smartphone applications that claim to be able to diagnose melanoma should be treated with extreme caution, say researchers. (Source: MedWire News - Oncology)
Clinical Impact of Circulating miR-221 in Plasma of Patients With Pancreatic Cancer
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Japanese authors suggested that expression of the micro-RNA miR-221 in patients with pancreatic cancer may predict tumor resectability, as well as serve as a biomarker for pancreatic cancer detection. Abstract Background:... (Source: OncologySTAT Journal Scans)
Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma.
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Authors: Nishida N, Kudo M Abstract Hepatocellular carcinoma (HCC) typically develops in the liver with chronic hepatitis and cirrhosis, and activation of oncogenes and inactivation of tumor suppressor genes occurs during carcinogenesis via genetic and epigenetic mechanisms. Recent advancements in the development of analyses for examining the cancer genome have revealed information regarding genetic alterations in HCC tissues. According to previous studies, the incidence of recurrent genetic alterations in individual genes was thought to be relatively rare and limited to a subset of a few cancer-specific genes such as tumor suppressor p53, RB genes and oncogenes such as CTNNB1. However, recent whole-genome analyses and exome sequencing of tumor DNA have revealed numerous novel alte...
Induction Chemotherapy Followed by Either Chemoradiotherapy or Bioradiotherapy for Larynx Preservation: The TREMPLIN Randomized Phase II Study
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In this randomized, phase II trial in patients with squamous cell carcinoma of the larynx or hypopharynx, chemoradiotherapy with cisplatin and bioradiotherapy with cetuximab resulted in similar rates of... (Source: OncologySTAT Journal Scans)
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Certain Skin Cancers More Common in HIV-Positive People
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Large study found higher rates of squamous cell, basal cell carcinomas (Source: The Doctors Lounge - Oncology)
Prognostic and Predictive Value of Tumor VEGF Gene Amplification in Metastatic Breast Cancer Treated With Paclitaxel With and Without Bevacizumab; Results From ECOG 2100 Trial
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A retrospective analysis of data from a phase III study showed that amplification of VEGFA was associated with poor survival outcomes in patients with metastatic breast cancer who received bevacizumab... (Source: OncologySTAT Journal Scans)
Breast cancer genes modify age at menopause
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Women with the BRCA1 or BRCA2 mutation begin menopause at a significantly younger median age than noncarriers, US researchers warn. (Source: MedWire News - Breast Cancer)
Role of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic Acid-enhanced magnetic resonance imaging in the management of hepatocellular carcinoma: consensus at the symposium of the 48th annual meeting of the liver cancer study group of Japan.
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Authors: Kudo M, Matsui O, Sakamoto M, Kitao A, Kim T, Ariizumi S, Ichikawa T, Kobayashi S, Imai Y, Izumi N, Fujinaga Y, Arii S Abstract We summarize here the consensus reached at the Symposium of the 48th Annual Meeting of the Liver Cancer Study Group of Japan held in Kanazawa on July 20th and 21st, 2012, on the role of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI) in the management of hepatocellular carcinoma (HCC). Currently, dynamic CT is the first choice of imaging modality when HCC is suspected. EOB-MRI is useful for differentiation and definitive diagnosis of HCC when dynamic CT/MRI does not show conclusive findings for HCC. In addition, contrast- enhanced ultrasound with Sonazoid is useful for making a decision on ...
Characterisation of Walker 256 breast carcinoma cells from two tumour cell banks as assessed using two models of secondary brain tumours
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Conclusions: These findings indicate that immortalised cancer cell lines obtained from different cell banks may have diverse characteristics and behaviour in vivo. (Source: Cancer Cell International)
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Women Catch Up to Men in Smoking-Related Mortality Risk
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Women have caught up to men with regard to the risk of death from cigarette smoking, according to analyses of three study cohorts spanning multiple decades and hundreds of thousands of individuals. (Source: Cancer Network)
Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters
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Abstract Oncolytic viruses (OVs) are novel cancer therapeutics with great promise, but host antiviral immunity represents the hurdle for their efficacy. Immunosuppression by cyclophosphamide (CP) has thus been shown to enhance the oncolytic efficacy of many OVs, but its effects on OVs armed with therapeutic genes remain unknown. We have previously reported on the efficacy of AxE1CAUP, an oncolytic adenovirus (OAd) expressing uracil phosphoribosyltransferase (UPRT), an enzyme that markedly enhanced the toxicity of 5‐fluorouracil (5‐FU), in immunodeficient, Ad‐nonpermissive nude mice. Here we explored the efficacy and safety of intratumoral (i.t.) AxE1CAUP/5‐FU therapy and of its combination with CP for syngenic HaP‐T1 pancreatic cancers in immunocompetent, Ad‐permissive Syrian h...
Reproducibility of the WHO classification of thymomas: Practical implications
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Conclusions: In this study, the agreement on WHO classification of thymomas was only moderate and this impacted on patients management. Web consensus conference on the diagnosis, more stringent diagnostic criteria or the adoption of referral diagnostic centres may substantially reduce discrepancies. (Source: Lung Cancer)
HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients
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Authors: V Martin, L Landi, F Molinari, G Fountzilas, R Geva, A Riva, P Saletti, S De Dosso, A Spitale, S Tejpar, K T Kalogeras, L Mazzucchelli, M Frattini & F Cappuzzo (Source: British Journal of Cancer AOP)